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KMID : 0624620140470030167
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BMB Reports
2014 Volume.47 No. 3 p.167 ~ p.172
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Structural insights into the transcription-independent apoptotic pathway of p53
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Chi Seung-Wook
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Abstract
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Reactivating the p53 pathway in tumors is an important strategy for anticancer therapy. In response to diverse cellular stresses, the tumor suppressor p53 mediates apoptosis in a transcriptionindependent and transcription-dependent manner. Although extensive studies have focused on the transcription-dependent apoptotic pathway of p53, the transcription-independent apoptotic pathway of p53 has only recently been discovered. Molecular interactions between p53 and Bcl-2 family proteins in the mitochondria play an essential role in the transcriptionindependent apoptosis of p53. This review describes the structural basis for the transcription-independent apoptotic pathway of p53 and discusses its potential application to anticancer therapy.
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KEYWORD
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Anticancer therapy, Apoptosis, Bcl-2 family proteins, p53, Structure
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